期刊簡(jiǎn)介預(yù)計(jì)審稿時(shí)間： 偏慢,4-8周

Mutation Research (MR) provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs.

MR publishes articles in the following areas:

Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.

Mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing.

Landscape of somatic mutations and epimutations in cancer and aging.

Role of de novo mutations in human disease and aging; mutations in population genomics.

Interactions between mutations and epimutations.

The role of epimutations in chromatin structure and function.

Mitochondrial DNA mutations and their consequences in terms of human disease and aging.

Novel ways to generate mutations and epimutations in cell lines and animal models.

突變研究 (MR) 提供了一個(gè)平臺(tái)，用于發(fā)布 DNA 突變和表觀(guān)突變的各個(gè)方面，從基本的進(jìn)化方面到遺傳和表觀(guān)遺傳診斷和治療中的轉(zhuǎn)化應(yīng)用。突變被定義為 DNA 序列和序列組織的所有可能改變，從點(diǎn)突變到基因組結(jié)構(gòu)變異、染色體畸變和非整倍性。表觀(guān)突變被定義為表觀(guān)基因組的改變，即 DNA 甲基化、組蛋白修飾和小調(diào)節(jié) RNA 的變化。

MR 在以下領(lǐng)域發(fā)表文章：

特別令人感興趣的是 DNA 損傷和突變影響發(fā)育和分化、干細(xì)胞生物學(xué)和細(xì)胞命運(yùn)的基本機(jī)制，包括各種形式的細(xì)胞死亡和細(xì)胞衰老。

人類(lèi)分子流行病學(xué)中基因組不穩(wěn)定性的研究以及與人類(lèi)疾病等復(fù)雜表型的關(guān)系被認(rèn)為是一個(gè)日益重要的領(lǐng)域。

（表觀(guān)）突變誘導(dǎo)機(jī)制，例如在 DNA 修復(fù)、復(fù)制或重組過(guò)程中；檢測(cè)（表觀(guān)）突變的新方法，重點(diǎn)是超高通量測(cè)序。

癌癥和衰老中的體細(xì)胞突變和表觀(guān)突變概況。

新生突變?cè)谌祟?lèi)疾病和衰老中的作用；群體基因組學(xué)中的突變。

突變和表觀(guān)突變之間的相互作用。

表觀(guān)突變?cè)谌旧|(zhì)結(jié)構(gòu)和功能中的作用。

線(xiàn)粒體 DNA 突變及其對(duì)人類(lèi)疾病和衰老的影響。

在細(xì)胞系和動(dòng)物模型中產(chǎn)生突變和表觀(guān)突變的新方法。

《Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis》(突變研究-突變發(fā)生的基本和分子機(jī)制)編輯部通訊方式為ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE。如果您需要協(xié)助投稿或潤(rùn)稿服務(wù)，您可以咨詢(xún)我們的客服老師。我們專(zhuān)注于期刊咨詢(xún)服務(wù)十年，熟悉發(fā)表政策，可為您提供一對(duì)一投稿指導(dǎo)，避免您在投稿時(shí)頻繁碰壁，節(jié)省您的寶貴時(shí)間，有效提升發(fā)表機(jī)率，確保SCI檢索（檢索不了全額退款）。我們視信譽(yù)為生命，多方面確保文章安全保密，在任何情況下都不會(huì)泄露您的個(gè)人信息或稿件內(nèi)容。