期刊簡介預計審稿時間： 較慢,6-12周

Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.

核苷酸和核苷是原始的生物分子，在進化早期既用作細胞內能量來源，又用作細胞外信號分子。ATP 最初被確定為一種神經遞質，后來被確定為外周和中樞神經系統中所有已確定的神經遞質的共同遞質。目前已確定了四種 P1（腺苷）受體亞型、七種 P2X 離子通道受體亞型和八種 P2Y G 蛋白偶聯受體亞型。自 20 世紀 90 年代初首次克隆出 P2 受體以來，有明確證據表明 P1 和 P2 受體亞型廣泛分布于神經元和非神經元細胞中，包括神經膠質細胞、免疫細胞、骨骼細胞、肌肉細胞、內皮細胞、上皮細胞和內分泌細胞。

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